ULK1 anticorps (N-Term)

N° du produit ABIN2785618

Cet anticorps Lapin Polyclonal détecte spécifiquement ULK1 dans WB. Il présente une réactivité envers Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin et Poisson zèbre (Danio rerio).

Aperçu rapide pour ULK1 anticorps (N-Term) (ABIN2785618)

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Reactivité: Humain, Souris, Rat, Boeuf (Vache), Chien, Cobaye, Cheval, Lapin, Poisson zèbre (Danio rerio)

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ULK1 est non-conjugé

Application: Western Blotting (WB)

Détail du produit anti-ULK1 anticorps

Épitope: N-Term

Séquence: PEVIMSQHYD GKADLWSIGT IVYQCLTGKA PFQASSPQDL RLFYEKNKTL

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

Attributs du produit: This is a rabbit polyclonal antibody against ULK1. It was validated on Western Blot.

Purification: Affinity Purified

Immunogène: The immunogen is a synthetic peptide directed towards the N-terminal region of Human ULK1

Information d'application

Indications d'application: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Conseil sur la manipulation: Avoid repeat freeze-thaw cycles.

Stock: -20 °C

Stockage commentaire: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Détails sur ULK1

Antigène: ULK1 (Unc-51 Like Kinase 1 (ULK1))

Autre désignation: ULK1

Sujet: ULK1 is a serine/threonine-protein kinase involved in autophagy in response to starvation. It acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. It is activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. It may phosphorylate ATG13/KIAA0652 and RPTOR, however such data need additional evidences and plays a role early in neuronal differentiation and is required for granule cell axon formation.
Alias Symbols: ATG1, ATG1A, UNC51, Unc51.1, hATG1
Protein Interaction Partner: SESN2, SQSTM1, ATG16L1, EXOC8, EXOC2, BECN1, RALB, AMBRA1, ULK1, UBC, TRAF6, MBP, ATG13, MAP1LC3C, MAP1LC3A, MAP1LC3B, GABARAPL1, GABARAPL2, GABARAP, MLST8, RPTOR, MTOR, PPP1CA, ATG4B, CDC37, G3BP1, RB1CC1, USP10, PRKAG1, PRKAB2, PRKAA2, PRKAA1, SYNGAP1,
Protein Size: 1050

Poids moléculaire: 112 kDa

ID gène: 8408

NCBI Accession: NM_003565, NP_003556

UniProt: O75385

Pathways: Regulation of Cell Size, Autophagy